The hip fracture risk factors are generally similar among those with and without Alzheimer’s disease, according to a recent study from the University of Eastern Finland. However, the incidence of hip fracture is higher among those with Alzheimer’s disease, regardless of other characteristics. Alzheimer’s disease itself appears to be such a significant risk factor for hip fracture that the relative impact of other risk factors is considerably smaller among those with Alzheimer’s disease.
Older persons, men, and those with mental and behavioural disorders or using antipsychotics or antidepressants had a higher hip fracture risk both among persons with and without Alzheimer’s disease, but the relative risk increase was higher among persons without Alzheimer’s disease. Stroke, diabetes, active cancer treatment, and the use of proton pump inhibitors, antiepileptics or opioids were associated with a higher hip fracture risk only in those without Alzheimer’s disease.
The findings are based on the MEDALZ study, including all community-dwellers of Finland who received a clinically verified diagnosis of Alzheimer’s disease in 2005-2011 and had no history of previous hip fracture (N=67,072) and a matched cohort of persons without Alzheimer’s disease.
Previously, many risk factors for hip fracture, including dementia, had been identified. It was not known whether the same factors predict hip fracture risk in persons with and without Alzheimer’s disease, which is the most common form of dementia